Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum X

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0086542	0.1244950	0.9452379
Weighted median	23	-0.0239486	0.0593612	0.6866259
Inverse variance weighted	23	0.0008728	0.0475489	0.9853558
Simple mode	23	0.0152007	0.1196525	0.9000626
Weighted mode	23	-0.0354457	0.0748792	0.6406118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.24995	21	0.0340676
Inverse variance weighted	34.26123	22	0.0461998

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000585	0.0070369	0.934529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010382	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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