Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum VIIb

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0666899 0.1589290 0.6790241
Weighted median 23 -0.0289651 0.0598144 0.6282087
Inverse variance weighted 23 -0.0870973 0.0607186 0.1514465
Simple mode 23 -0.0516696 0.0938260 0.5873913
Weighted mode 23 -0.0347571 0.0625558 0.5840787

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 55.81725 21 5.37e-05
Inverse variance weighted 55.86897 22 8.93e-05

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0012532 0.0089831 0.8903821

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.001851 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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