Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum VIIIb

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1724362	0.1674102	0.3147177
Weighted median	23	-0.1174188	0.0635748	0.0647559
Inverse variance weighted	23	-0.1014380	0.0642508	0.1143858
Simple mode	23	-0.1763333	0.1140270	0.1362690
Weighted mode	23	-0.1638848	0.0859270	0.0696284

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	61.93332	21	6.5e-06
Inverse variance weighted	62.55940	22	9.3e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043599	0.0094627	0.649715

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021096	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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