Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum VIIIa

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1338668	0.1401681	0.3504207
Weighted median	23	-0.0579507	0.0537139	0.2806424
Inverse variance weighted	23	-0.0975885	0.0536263	0.0687914
Simple mode	23	-0.0478012	0.0864871	0.5860431
Weighted mode	23	-0.0631864	0.0565831	0.2761702

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.41545	21	0.0027812
Inverse variance weighted	43.57891	22	0.0040020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022278	0.0079227	0.7813188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015191	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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