Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum VI

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1218486	0.1176781	0.3122404
Weighted median	23	0.0271153	0.0555062	0.6251890
Inverse variance weighted	23	0.0179984	0.0459106	0.6950358
Simple mode	23	0.0232588	0.0921123	0.8029951
Weighted mode	23	0.0491303	0.0647227	0.4558567

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.60113	21	0.0805572
Inverse variance weighted	31.94062	22	0.0784140

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063773	0.0066515	0.3485877

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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