Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum V

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0311735	0.0974856	0.7522984
Weighted median	23	-0.0209825	0.0534406	0.6945917
Inverse variance weighted	23	-0.0097137	0.0381028	0.7987747
Simple mode	23	-0.0457793	0.0786815	0.5665958
Weighted mode	23	-0.0187093	0.0600424	0.7582766

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.44469	21	0.4932717
Inverse variance weighted	20.50188	22	0.5516770

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013178	0.0055102	0.813302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8