Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum IX

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0540524	0.1654904	0.7471885
Weighted median	23	-0.1024410	0.0637805	0.1082412
Inverse variance weighted	23	-0.0568335	0.0631961	0.3684823
Simple mode	23	-0.0913772	0.1103647	0.4165866
Weighted mode	23	-0.0851403	0.0700337	0.2369822

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	60.52130	21	1.06e-05
Inverse variance weighted	60.52227	22	1.87e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001708	0.0093541	0.9856057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019012	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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