Two sample MR report

Telomere_length against IDP T1 FAST ROIs R cerebellum I-IV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0673419	0.1089477	0.5431479
Weighted median	23	0.0135069	0.0526101	0.7973820
Inverse variance weighted	23	0.0200660	0.0423495	0.6356297
Simple mode	23	0.0231742	0.0750954	0.7605318
Weighted mode	23	0.0138478	0.0595632	0.8183071

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.22872	21	0.197862
Inverse variance weighted	27.17761	22	0.204558

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053675	0.0061581	0.3932679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008319	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8