Two sample MR report

Telomere_length against IDP T1 FAST ROIs R caudate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0380366	0.1088885	0.7303298
Weighted median	23	-0.0285753	0.0546990	0.6013849
Inverse variance weighted	23	-0.0226463	0.0416045	0.5862194
Simple mode	23	-0.0313901	0.1001373	0.7568757
Weighted mode	23	-0.0866316	0.0676123	0.2134302

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.20051	21	0.1989065
Inverse variance weighted	26.22993	22	0.2419410

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009451	0.0061548	0.8794263

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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