Two sample MR report

Telomere_length against IDP T1 FAST ROIs R angular gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0852044	0.1278439	0.5123658
Weighted median	23	-0.1153257	0.0617443	0.0617906
Inverse variance weighted	23	-0.0282178	0.0490918	0.5654281
Simple mode	23	-0.1223005	0.1268104	0.3453097
Weighted mode	23	-0.1151264	0.0736879	0.1324764

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.11755	21	0.0212097
Inverse variance weighted	36.52090	22	0.0266821

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034995	0.0072262	0.6332034

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011233	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8