Two sample MR report

Telomere_length against IDP T1 FAST ROIs R amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1305310	0.1126871	0.2597257
Weighted median	23	0.0045194	0.0560539	0.9357397
Inverse variance weighted	23	-0.0010381	0.0446500	0.9814507
Simple mode	23	0.0117582	0.0931933	0.9007433
Weighted mode	23	0.0117582	0.0590540	0.8440061

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.06054	21	0.1384426
Inverse variance weighted	30.21052	22	0.1134367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080795	0.0063695	0.2185134

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009154	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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