Two sample MR report

Telomere_length against IDP T1 FAST ROIs L ventral striatum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0892094	0.1137376	0.4415966
Weighted median	23	-0.0947531	0.0542021	0.0804387
Inverse variance weighted	23	-0.0644056	0.0434908	0.1386324
Simple mode	23	-0.1306478	0.1009196	0.2088911
Weighted mode	23	-0.1046951	0.0664572	0.1294420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.58622	21	0.1242952
Inverse variance weighted	28.66263	22	0.1547473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015232	0.0064288	0.8150103

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009551	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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