Two sample MR report

Telomere_length against IDP T1 FAST ROIs L thalamus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0813284	0.1323317	0.5454344
Weighted median	23	0.0706850	0.0587982	0.2293003
Inverse variance weighted	23	0.0552248	0.0505885	0.2749887
Simple mode	23	0.0687648	0.0964227	0.4832439
Weighted mode	23	0.0731830	0.0691917	0.3016751

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.69702	21	0.0106656
Inverse variance weighted	38.78165	22	0.0149467

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001603	0.0074798	0.8323755

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012388	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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