Two sample MR report

Telomere_length against IDP T1 FAST ROIs L temporal pole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0864087	0.1484040	0.5665957
Weighted median	23	-0.0119853	0.0594193	0.8401450
Inverse variance weighted	23	0.0442507	0.0578928	0.4446556
Simple mode	23	0.1102591	0.1218582	0.3753658
Weighted mode	23	-0.0095053	0.0661127	0.8869882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.66976	21	0.0005570
Inverse variance weighted	50.79022	22	0.0004581

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080236	0.0083883	0.349692

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015798	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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