Two sample MR report

Telomere_length against IDP T1 FAST ROIs L supramarg gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0495475	0.1045820	0.6405546
Weighted median	23	-0.1306230	0.0545933	0.0167268
Inverse variance weighted	23	-0.0649116	0.0399609	0.1042955
Simple mode	23	-0.0823250	0.0966638	0.4035764
Weighted mode	23	-0.1114964	0.0663643	0.1070906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.16949	21	0.2849190
Inverse variance weighted	24.19881	22	0.3368952

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009435	0.0059113	0.8747161

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008212	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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