Two sample MR report

Telomere_length against IDP T1 FAST ROIs L supramarg gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0330943	0.0974856	0.7376202
Weighted median	23	-0.0247526	0.0525551	0.6376525
Inverse variance weighted	23	0.0107060	0.0381028	0.7787289
Simple mode	23	-0.0396256	0.0834167	0.6394458
Weighted mode	23	-0.0135296	0.0608041	0.8259685

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.87780	21	0.7764771
Inverse variance weighted	16.11607	22	0.8100835

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026897	0.0055102	0.6305155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004908	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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