Two sample MR report

Telomere_length against IDP T1 FAST ROIs L sup parietal lobule

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0404516	0.0974844	0.6823839
Weighted median	23	0.0186834	0.0551986	0.7350046
Inverse variance weighted	23	0.0182059	0.0381027	0.6327849
Simple mode	23	0.1143108	0.0938127	0.2359400
Weighted mode	23	-0.0003952	0.0702039	0.9955593

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.57243	21	0.6758781
Inverse variance weighted	17.99977	22	0.7060021

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036021	0.0055101	0.5203908

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005524	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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