Two sample MR report

Telomere_length against IDP T1 FAST ROIs L sup front gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1300095	0.1109813	0.2545368
Weighted median	23	-0.0154116	0.0520151	0.7670076
Inverse variance weighted	23	0.0228030	0.0445813	0.6090062
Simple mode	23	-0.0165964	0.0860944	0.8489080
Weighted mode	23	-0.0233778	0.0570801	0.6860888

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.21728	21	0.1637766
Inverse variance weighted	30.11757	22	0.1156348

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093839	0.006273	0.1495529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009235	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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