Two sample MR report

Telomere_length against IDP T1 FAST ROIs L putamen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0822009	0.1175179	0.4919307
Weighted median	23	-0.1549900	0.0596809	0.0094047
Inverse variance weighted	23	-0.1025849	0.0449142	0.0223703
Simple mode	23	-0.1722839	0.1208360	0.1679714
Weighted mode	23	-0.1968091	0.0981142	0.0573156

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.51849	21	0.0820535
Inverse variance weighted	30.57010	22	0.1052536

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012518	0.0066426	0.852337

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001146	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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