Two sample MR report

Telomere_length against IDP T1 FAST ROIs L precentral gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0068042	0.1103907	0.9514347
Weighted median	23	-0.0500538	0.0543318	0.3569133
Inverse variance weighted	23	-0.0298442	0.0422064	0.4795038
Simple mode	23	-0.0180958	0.0936247	0.8485125
Weighted mode	23	-0.0329147	0.0655793	0.6207193

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.92825	21	0.1732408
Inverse variance weighted	26.99418	22	0.2114477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014148	0.0062396	0.8228099

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008365	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8