Two sample MR report

Telomere_length against IDP T1 FAST ROIs L postcent gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0990508	0.1142257	0.3956608
Weighted median	23	-0.0809737	0.0548555	0.1399099
Inverse variance weighted	23	-0.0219786	0.0441738	0.6188019
Simple mode	23	-0.0725527	0.0986783	0.4699565
Weighted mode	23	-0.0922989	0.0631734	0.1581405

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.83197	21	0.1180944
Inverse variance weighted	29.56974	22	0.1293024

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047328	0.0064564	0.4716335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009061	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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