Two sample MR report

Telomere_length against IDP T1 FAST ROIs L planum temporale

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1087552	0.1040351	0.3077361
Weighted median	23	-0.1203112	0.0582274	0.0388069
Inverse variance weighted	23	-0.0494386	0.0400892	0.2174952
Simple mode	23	-0.1373819	0.0993845	0.1807454
Weighted mode	23	-0.1644275	0.0828196	0.0597080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.91712	21	0.2970917
Inverse variance weighted	24.35412	22	0.3289448

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036425	0.0058804	0.5422927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000789	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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