Two sample MR report

Telomere_length against IDP T1 FAST ROIs L planum polare

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0352646	0.0974842	0.7211553
Weighted median	23	-0.0720820	0.0540015	0.1819373
Inverse variance weighted	23	-0.0384538	0.0381024	0.3128679
Simple mode	23	-0.0023082	0.0977062	0.9813659
Weighted mode	23	-0.0776356	0.0742277	0.3069578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.40302	21	0.5593039
Inverse variance weighted	19.40428	22	0.6202491

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001958	0.0055102	0.9719828

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006189	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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