Two sample MR report

Telomere_length against IDP T1 FAST ROIs L parahipp gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0230382	0.1013821	0.8224334
Weighted median	23	0.0154529	0.0536071	0.7731459
Inverse variance weighted	23	0.0516639	0.0388013	0.1830252
Simple mode	23	-0.0112767	0.0799234	0.8890796
Weighted mode	23	0.0108544	0.0653910	0.8696796

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.71235	21	0.3595048
Inverse variance weighted	22.81412	22	0.4122883

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017579	0.0057305	0.7620503

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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