Two sample MR report

Telomere_length against IDP T1 FAST ROIs L parahipp gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0315664	0.1066055	0.7700583
Weighted median	23	-0.0094386	0.0542372	0.8618458
Inverse variance weighted	23	0.0071195	0.0407700	0.8613745
Simple mode	23	0.0081830	0.0888570	0.9274587
Weighted mode	23	-0.0202031	0.0581825	0.7317132

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.11389	21	0.2422649
Inverse variance weighted	25.18813	22	0.2881632

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015013	0.0060257	0.8056722

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007643	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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