Two sample MR report

Telomere_length against IDP T1 FAST ROIs L paracing gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0456406	0.1066081	0.6729253
Weighted median	23	0.0135676	0.0577923	0.8143910
Inverse variance weighted	23	-0.0045803	0.0408802	0.9107906
Simple mode	23	0.0831879	0.1127212	0.4683160
Weighted mode	23	0.0450134	0.1002046	0.6576706

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.11558	21	0.2421929
Inverse variance weighted	25.32499	22	0.2817874

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025215	0.0060259	0.6798742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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