Two sample MR report

Telomere_length against IDP T1 FAST ROIs L pallidum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1254363	0.0974853	0.2121963
Weighted median	23	0.0446114	0.0523705	0.3943010
Inverse variance weighted	23	0.0649997	0.0381026	0.0880247
Simple mode	23	0.0395346	0.0865714	0.6523848
Weighted mode	23	0.0395346	0.0611790	0.5248262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.55178	21	0.7942824
Inverse variance weighted	16.00543	22	0.8156162

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037113	0.0055102	0.5079539

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005732	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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