Two sample MR report

Telomere_length against IDP T1 FAST ROIs L occ pole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2438061	0.1129468	0.0426069
Weighted median	23	-0.0799928	0.0628328	0.2029804
Inverse variance weighted	23	-0.0503468	0.0465515	0.2794619
Simple mode	23	0.0346280	0.1050416	0.7447749
Weighted mode	23	0.0070195	0.0905996	0.9389435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.19075	21	0.1348239
Inverse variance weighted	32.83929	22	0.0641705

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.01188	0.0063842	0.0768236

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010479	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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