Two sample MR report

Telomere_length against IDP T1 FAST ROIs L occ fusif gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0203851	0.1019015	0.8433682
Weighted median	23	0.0707779	0.0591448	0.2314282
Inverse variance weighted	23	0.0459825	0.0389821	0.2381673
Simple mode	23	0.0564062	0.1056019	0.5986013
Weighted mode	23	0.0643205	0.0761784	0.4075671

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.94602	21	0.3468633
Inverse variance weighted	23.02740	22	0.4001839

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015719	0.0057598	0.7875907

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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