Two sample MR report

Telomere_length against IDP T1 FAST ROIs L mid front gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1537617	0.1532403	0.3270890
Weighted median	23	-0.0472283	0.0620077	0.4462678
Inverse variance weighted	23	-0.0936502	0.0587704	0.1110496
Simple mode	23	0.0151665	0.1063958	0.8879448
Weighted mode	23	-0.0659614	0.0698096	0.3549848

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.89357	21	0.0001977
Inverse variance weighted	52.34238	22	0.0002803

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036914	0.0086618	0.6743194

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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