Two sample MR report

Telomere_length against IDP T1 FAST ROIs L lingual gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0219108	0.1153072	0.8511175
Weighted median	23	0.0239176	0.0573666	0.6767330
Inverse variance weighted	23	0.0236140	0.0442246	0.5933707
Simple mode	23	0.0153795	0.0895290	0.8651787
Weighted mode	23	-0.0017413	0.0586367	0.9765774

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.3801	21	0.1051710
Inverse variance weighted	29.6375	22	0.1275444

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027956	0.0065175	0.6723393

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009097	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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