Two sample MR report

Telomere_length against IDP T1 FAST ROIs L hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2262466	0.1130901	0.0585320
Weighted median	23	0.0976936	0.0566290	0.0845000
Inverse variance weighted	23	0.0501909	0.0460333	0.2755734
Simple mode	23	0.1368744	0.0881261	0.1346522
Weighted mode	23	0.0843976	0.0675922	0.2249255

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.26200	21	0.1328760
Inverse variance weighted	32.11176	22	0.0755106

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108112	0.0063922	0.1055651

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010256	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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