Two sample MR report

Telomere_length against IDP T1 FAST ROIs L heschl gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0493766	0.0985243	0.6214705
Weighted median	23	-0.0494428	0.0535178	0.3555603
Inverse variance weighted	23	-0.0377459	0.0381027	0.3218641
Simple mode	23	-0.0813245	0.0958636	0.4053868
Weighted mode	23	-0.0592222	0.0614254	0.3454590

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.45001	21	0.4317733
Inverse variance weighted	21.46681	22	0.4920710

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007142	0.0055689	0.8991706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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