Two sample MR report

Telomere_length against IDP T1 FAST ROIs L frontal pole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0026583	0.1126704	0.9813994
Weighted median	23	-0.1012967	0.0585327	0.0835229
Inverse variance weighted	23	-0.0020030	0.0430279	0.9628715
Simple mode	23	0.0140577	0.1150390	0.9038508
Weighted mode	23	-0.0890569	0.0671671	0.1984754

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.05277	21	0.1386611
Inverse variance weighted	28.05547	22	0.1738503

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002862	0.0063685	0.9645746

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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