Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cing gyrus post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0880712	0.1275238	0.4973641
Weighted median	23	0.0459981	0.0627767	0.4637263
Inverse variance weighted	23	-0.0128391	0.0491719	0.7940098
Simple mode	23	0.1007621	0.1058097	0.3512934
Weighted mode	23	0.0485838	0.0873726	0.5837865

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.93719	21	0.0222231
Inverse variance weighted	36.64017	22	0.0258975

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046199	0.0072081	0.5285007

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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