Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cing gyrus ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0460333	0.0974841	0.6416445
Weighted median	23	-0.0353605	0.0553714	0.5230787
Inverse variance weighted	23	-0.0378375	0.0381023	0.3206865
Simple mode	23	-0.0133632	0.1113769	0.9055864
Weighted mode	23	0.0362830	0.0834494	0.6679494

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.75168	21	0.6646596
Inverse variance weighted	17.76003	22	0.7201178

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005033	0.0055102	0.9280882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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