Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum crus II

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0192110	0.1703285	0.9112700
Weighted median	23	0.0003611	0.0633209	0.9954504
Inverse variance weighted	23	-0.0629785	0.0654679	0.3360619
Simple mode	23	-0.2394739	0.1333658	0.0863051
Weighted mode	23	0.0133864	0.0638787	0.8359400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	64.11201	21	3e-06
Inverse variance weighted	64.95104	22	4e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005047	0.0096274	0.6056027

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020507	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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