Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum crus I

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1731630	0.0974836	0.0901706
Weighted median	23	0.0658972	0.0567779	0.2457993
Inverse variance weighted	23	0.0318032	0.0381024	0.4039004
Simple mode	23	0.0123348	0.1004502	0.9033844
Weighted mode	23	0.0774493	0.0768241	0.3243487

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.88906	21	0.6560136
Inverse variance weighted	20.37098	22	0.5598461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086808	0.0055102	0.1301074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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