Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum X

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0834978	0.1526864	0.5902405
Weighted median	23	-0.0388800	0.0657808	0.5544844
Inverse variance weighted	23	-0.0466512	0.0584029	0.4244165
Simple mode	23	-0.1211739	0.1245773	0.3412862
Weighted mode	23	-0.0629756	0.0933624	0.5070021

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.52176	21	0.0002232
Inverse variance weighted	51.69040	22	0.0003449

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022627	0.0086304	0.7957382

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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