Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum VIIb

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0454303	0.1619026	0.7817610
Weighted median	23	-0.0409293	0.0566359	0.4698795
Inverse variance weighted	23	-0.1031815	0.0620462	0.0963167
Simple mode	23	0.0282119	0.1010312	0.7826695
Weighted mode	23	-0.0360564	0.0549959	0.5188673

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	57.92493	21	2.62e-05
Inverse variance weighted	58.33918	22	3.92e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035463	0.0091511	0.7022631

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019897	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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