Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum VIIIb

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1930764	0.1506579	0.2139690
Weighted median	23	-0.0447527	0.0583532	0.4431246
Inverse variance weighted	23	-0.0889575	0.0582983	0.1270342
Simple mode	23	0.0480572	0.0935823	0.6127007
Weighted mode	23	-0.0085749	0.0776067	0.9130212

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.15826	21	0.0003468
Inverse variance weighted	51.50473	22	0.0003658

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063938	0.0085158	0.461092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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