Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum VIIIa

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2013893	0.1344257	0.1489773
Weighted median	23	-0.0984998	0.0534483	0.0653438
Inverse variance weighted	23	-0.1059978	0.0520543	0.0417210
Simple mode	23	-0.0472967	0.0937059	0.6187628
Weighted mode	23	-0.1051367	0.0562986	0.0752149

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.93196	21	0.0075797
Inverse variance weighted	41.06216	22	0.0081018

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058578	0.0075982	0.4493242

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014785	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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