Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum VI

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1326507	0.1090622	0.2373716
Weighted median	23	0.0098881	0.0534874	0.8533332
Inverse variance weighted	23	-0.0083334	0.0435595	0.8482820
Simple mode	23	-0.1522935	0.1069879	0.1686296
Weighted mode	23	0.0140618	0.0656318	0.8323231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.28407	21	0.1958241
Inverse variance weighted	28.75273	22	0.1520568

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086576	0.0061645	0.1748144

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008727	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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