Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum V

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0700173	0.1035022	0.5061183
Weighted median	23	-0.0444726	0.0539168	0.4094635
Inverse variance weighted	23	-0.0339173	0.0396590	0.3924270
Simple mode	23	-0.0653047	0.0945634	0.4970445
Weighted mode	23	-0.0361511	0.0635025	0.5749286

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.67225	21	0.3092084
Inverse variance weighted	23.83411	22	0.3559849

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022168	0.0058503	0.7085459

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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