Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum IX

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1002132	0.1531982	0.5201212
Weighted median	23	-0.0422897	0.0631867	0.5033160
Inverse variance weighted	23	-0.0417467	0.0587406	0.4772728
Simple mode	23	0.0208216	0.1011473	0.8387978
Weighted mode	23	-0.0150422	0.0758027	0.8445245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.86363	21	0.0001997
Inverse variance weighted	52.28820	22	0.0002852

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035903	0.0086593	0.6826237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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