Two sample MR report

Telomere_length against IDP T1 FAST ROIs L cerebellum I-IV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0194465	0.1052025	0.8551214
Weighted median	23	-0.0086833	0.0545973	0.8736346
Inverse variance weighted	23	-0.0214938	0.0401739	0.5926362
Simple mode	23	-0.0429765	0.0754648	0.5747922
Weighted mode	23	-0.0038408	0.0544642	0.9444171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.45634	21	0.2714767
Inverse variance weighted	24.45686	22	0.3237453

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001257	0.0059464	0.9833316

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007507	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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