Two sample MR report

Telomere_length against IDP T1 FAST ROIs L caudate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0689610	0.1033170	0.5117411
Weighted median	23	-0.0589869	0.0582751	0.3114349
Inverse variance weighted	23	-0.0351827	0.0395718	0.3739576
Simple mode	23	-0.0379668	0.0966475	0.6982201
Weighted mode	23	-0.0952946	0.0651946	0.1579628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.58808	21	0.3134422
Inverse variance weighted	23.72979	22	0.3615512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020743	0.0058399	0.7259878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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