Two sample MR report

Telomere_length against IDP T1 FAST ROIs L angular gyrus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0768905	0.0994073	0.4478530
Weighted median	23	-0.0997297	0.0569514	0.0799226
Inverse variance weighted	23	-0.0666876	0.0381021	0.0800776
Simple mode	23	-0.2106492	0.1044367	0.0560606
Weighted mode	23	-0.1527513	0.0650543	0.0282718

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.83744	21	0.4089291
Inverse variance weighted	21.85037	22	0.4688499

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006265	0.0056189	0.9122729

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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