Two sample MR report

Telomere_length against IDP T1 FAST ROIs L amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0190896	0.1097006	0.8635198
Weighted median	23	-0.0141686	0.0545149	0.7949386
Inverse variance weighted	23	-0.0194492	0.0418913	0.6424488
Simple mode	23	0.0533940	0.1025517	0.6078083
Weighted mode	23	-0.0377446	0.0628320	0.5541639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.59282	21	0.1847405
Inverse variance weighted	26.59284	22	0.2271003

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-2.21e-05	0.0062007	0.9971923

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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