Two sample MR report

Telomere_length against IDP SWI T2star right thalamus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1424086	0.1265428	0.2731266
Weighted median	23	0.0379820	0.0603371	0.5290237
Inverse variance weighted	23	0.0820468	0.0486320	0.0915854
Simple mode	23	-0.0406125	0.1025926	0.6960196
Weighted mode	23	-0.0123189	0.0820188	0.8819785

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.05311	21	0.0578293
Inverse variance weighted	32.46303	22	0.0698375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003708	0.0071552	0.6097128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011109	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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